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M9480162.TXT
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1994-08-09
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Document 0162
DOCN M9480162
TI A new approach to the limiting dilution assay.
DT 9410
AU Balch AH; Hitchcock MJ; Brockwell PJ; Bristol-Myers Squibb, PRI,
Wallingford, Connecticut.
SO J Biopharm Stat. 1994 Mar;4(1):101-12. Unique Identifier : AIDSLINE
MED/94290523
AB Improved methods of human immunodeficiency virus isolation have sparked
an increased interest in determination of the number and proportion of
infected cells in plasma samples. The limiting dilution assay is a
popular method of determining the proportion of infected cells. We
propose a new estimator of the proportion of infected cells based on an
underlying Markov chain model for the progression of infected cells to
further flasks in the series. This method should improve both design and
analyses of these assays.
DE Acquired Immunodeficiency Syndrome/*BLOOD/*MICROBIOLOGY Colony Count,
Microbial/METHODS Comparative Study Human HIV/*GROWTH & DEVELOPMENT
*Markov Chains Reproducibility of Results JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).